Thermotropic nematic LCs can modulate light in phases, amplitudes, and polarizations . Many photonic applications based LCs have developed, such as displays, electro-optical switches, lenses, optical vortex generators, variable optical attenuations, solar cells and so on. Thermotropic nematic LCs have great potential in bio-medical applications. In this session, we mainly introduce two the bio-medical applications based on thermotropic nematic LCs: biosensors and ophthalmic lenses. In biosensors, the key is interfacial interactions between biosamples and LC molecules. We will introduce a LC and polymer complex system, the LC and polymer composite film (LCPCF), whose surface free energy is electrically switchable. LCPCF can help to test the sperm quality and high-density-lipoprotein (HDL). In ophthalmic applications, we will introduce the challenges and requirements for design of ophthalmic lenses. A polarizer-free LC lens with large aperture size is also introduced.