In the literature, there are many EDA works related to the layout placement of analog VLSI circuits. However, few of them are discussing about the placement of high-voltage VLSI circuits. Compared with typical circuits, the design of high-voltage circuits often requires isolation rings around transistors for better protection. Because isolation rings will occupy large chip area, it is necessary to develop proper EDA tools for the placement optimization with isolation rings to reduce the chip cost. In this paper, a placement optimization flow is proposed to consider both symmetry constraints and isolation rings for the layout automation of high-voltage circuits. Through changing the location of transistors inside every isolation rings, different shapes of isolation rings will be considered simultaneously during the placement algorithm to optimize the layout area. According to the experimental results, the proposed placement algorithm is able to reduce the chip area for high-voltage designs with isolation rings and still keeps the algorithm efficiency.