Laser trapping and patterning of protein microcrystals: Toward highly integrated protein microarrays

Yoichiroh Hosokawa*, Satoshi Matsumura, Hiroshi Masuhara, Keiko Ikeda, Ai Shimo-Oka, Hajime Mori

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A highly integrated protein chip was fabricated using polyhedra bonded under a microscope by focused laser beams. The optical trapping was used with a 1064 nm Nd3+:YAG laser to trap and to transfer it in a polymer substrate. The polymer surface was mechanically and chemically modified by multiphoton absorption of a 120 fs, 800 nm femtosecond Ti:sapphire laser to bond the polyhedron on the substrate. A photochemical fixation of single polymers and gold nanoparticles was demonstrated by combining laser manipulation techniques with photopolymerization.

Original languageEnglish
Pages (from-to)2945-2948
Number of pages4
JournalJournal of Applied Physics
Volume96
Issue number5
DOIs
StatePublished - 1 Sep 2004

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