Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals

Hui Wen Su, Yun Han Lee, Mon Juan Lee*, Yi Chiang Hsu, Wei Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Än) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories

Original languageEnglish
Article number077006
JournalJournal of Biomedical Optics
Volume19
Issue number7
DOIs
StatePublished - 1 Jan 2014

Keywords

  • CA125
  • cancer biomarker
  • label-free immunodetection
  • liquid-crystal-based immunodetection

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