Iron embedded magnetic nanodiamonds for in vivo MRI contrast enhancement

Bo-Rong Lin, Chien-Hsu Chen, Chun-Hsiang Chang, Srinivasu Kunuku, Tzung-Yuang Chen, Tung-Yuan Hsiao, Hung-Kai Yu, Yu Jen Chang, Li Chuan Liao, Fang-Hsin Chen, Huan Niu*, Chien-Ping Lee

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Although nanodiamonds have long being considered as a potential tool for biomedical research, the practical in vivo magnetic resonance imaging (MRI) application of nanodiamonds remains relatively unexplored. In this paper, we present the first application of in vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds. An MR image enhancement was clearly demonstrated in the rendering of T2-weighted images of mice obtained using an unmodified commercial MRI scanner. The excellent contrast obtained using these nanodiamonds opens the door to the non-invasive in vivo tracking of nanodiamonds and image enhancement. In the future, one can apply these magnetic nanodiamonds together with surface modifications to facilitate drug delivery, targeted therapy, localized thermal treatment, and diagnostic imaging.
Original languageEnglish
Article number505402
JournalJournal Physics D: Applied Physics
Volume52
Issue number50
DOIs
StatePublished - 11 Dec 2019

Keywords

  • iron; nanodiamonds; ion implantation; in vivo; mri; contrast enhancement
  • FLUORESCENT NANODIAMONDS; BIOCOMPATIBILITY; TRACKING; AGENTS; TOOL

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    Lin, B-R., Chen, C-H., Chang, C-H., Kunuku, S., Chen, T-Y., Hsiao, T-Y., Yu, H-K., Chang, Y. J., Liao, L. C., Chen, F-H., Niu, H., & Lee, C-P. (2019). Iron embedded magnetic nanodiamonds for in vivo MRI contrast enhancement. Journal Physics D: Applied Physics, 52(50), [505402]. https://doi.org/10.1088/1361-6463/ab41e8