Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice

Olga Kosheleva, Tsung Ching Lai, Yung Chieh Chan, Michael Hsiao, Shok Li Ng, Chung Hsuan Chen, G. Chen*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The presence of nanoparticles within an ultrasonic field has been previously shown to cause ultrasound to preferentially destroy cancerous cells over corresponding normal cells. Such treatment, termed nanoparticle-assisted ultrasound therapy (NAUT), has now been applied to subcutaneously implanted tumors in mice. Xenografted tumors were exposed to therapeutic ultrasound, with and without intratumoral injections of nanoparticles over a period of 4 weeks. Post-treatment, tumors that received nanoparticle injections were found to be substantially smaller than controls, suggesting that nanoparticle presence significantly increases the efficacy of ultrasonic treatment of solid tumors.

Original languageEnglish
Title of host publication2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages672-674
Number of pages3
ISBN (Electronic)9781509030286
DOIs
StatePublished - 21 Nov 2017
Event17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States
Duration: 25 Jul 201728 Jul 2017

Publication series

Name2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

Conference

Conference17th IEEE International Conference on Nanotechnology, NANO 2017
CountryUnited States
CityPittsburgh
Period25/07/1728/07/17

Keywords

  • cancer
  • nanoparticle-assisted ultrasound therapy
  • ultrasound
  • ultrasound-nanoparticle interactions

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    Kosheleva, O., Lai, T. C., Chan, Y. C., Hsiao, M., Ng, S. L., Chen, C. H., & Chen, G. (2017). Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. In 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017 (pp. 672-674). [8117465] (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2017.8117465