Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice

Olga Kosheleva; Tsung Ching Lai; Yung Chieh Chan; Michael Hsiao; Shok Li Ng; Chung Hsuan Chen; G. Chen

doi:10.1109/NANO.2017.8117465

Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice

Olga Kosheleva, Tsung Ching Lai, Yung Chieh Chan, Michael Hsiao, Shok Li Ng, Chung Hsuan Chen, G. Chen^*

^*Corresponding author for this work

Department of Electrical and Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

The presence of nanoparticles within an ultrasonic field has been previously shown to cause ultrasound to preferentially destroy cancerous cells over corresponding normal cells. Such treatment, termed nanoparticle-assisted ultrasound therapy (NAUT), has now been applied to subcutaneously implanted tumors in mice. Xenografted tumors were exposed to therapeutic ultrasound, with and without intratumoral injections of nanoparticles over a period of 4 weeks. Post-treatment, tumors that received nanoparticle injections were found to be substantially smaller than controls, suggesting that nanoparticle presence significantly increases the efficacy of ultrasonic treatment of solid tumors.

Original language	English
Title of host publication	2017 IEEE 17th International Conference on Nanotechnology, NANO 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	672-674
Number of pages	3
ISBN (Electronic)	9781509030286
DOIs	https://doi.org/10.1109/NANO.2017.8117465
State	Published - 21 Nov 2017
Event	17th IEEE International Conference on Nanotechnology, NANO 2017 - Pittsburgh, United States Duration: 25 Jul 2017 → 28 Jul 2017

Publication series

Name	2017 IEEE 17th International Conference on Nanotechnology, NANO 2017

Conference

Conference	17th IEEE International Conference on Nanotechnology, NANO 2017
Country	United States
City	Pittsburgh
Period	25/07/17 → 28/07/17

Keywords

cancer
nanoparticle-assisted ultrasound therapy
ultrasound
ultrasound-nanoparticle interactions

Access to Document

10.1109/NANO.2017.8117465

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Kosheleva, O., Lai, T. C., Chan, Y. C., Hsiao, M., Ng, S. L., Chen, C. H., & Chen, G. (2017). Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. In 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017 (pp. 672-674). [8117465] (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NANO.2017.8117465

Kosheleva, Olga ; Lai, Tsung Ching ; Chan, Yung Chieh ; Hsiao, Michael ; Ng, Shok Li ; Chen, Chung Hsuan ; Chen, G. / Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 672-674 (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017).

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abstract = "The presence of nanoparticles within an ultrasonic field has been previously shown to cause ultrasound to preferentially destroy cancerous cells over corresponding normal cells. Such treatment, termed nanoparticle-assisted ultrasound therapy (NAUT), has now been applied to subcutaneously implanted tumors in mice. Xenografted tumors were exposed to therapeutic ultrasound, with and without intratumoral injections of nanoparticles over a period of 4 weeks. Post-treatment, tumors that received nanoparticle injections were found to be substantially smaller than controls, suggesting that nanoparticle presence significantly increases the efficacy of ultrasonic treatment of solid tumors.",

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author = "Olga Kosheleva and Lai, {Tsung Ching} and Chan, {Yung Chieh} and Michael Hsiao and Ng, {Shok Li} and Chen, {Chung Hsuan} and G. Chen",

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Kosheleva, O, Lai, TC, Chan, YC, Hsiao, M, Ng, SL, Chen, CH & Chen, G 2017, Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. in 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017., 8117465, 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017, Institute of Electrical and Electronics Engineers Inc., pp. 672-674, 17th IEEE International Conference on Nanotechnology, NANO 2017, Pittsburgh, United States, 25/07/17. https://doi.org/10.1109/NANO.2017.8117465

Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. / Kosheleva, Olga; Lai, Tsung Ching; Chan, Yung Chieh; Hsiao, Michael; Ng, Shok Li; Chen, Chung Hsuan; Chen, G.

2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 672-674 8117465 (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AB - The presence of nanoparticles within an ultrasonic field has been previously shown to cause ultrasound to preferentially destroy cancerous cells over corresponding normal cells. Such treatment, termed nanoparticle-assisted ultrasound therapy (NAUT), has now been applied to subcutaneously implanted tumors in mice. Xenografted tumors were exposed to therapeutic ultrasound, with and without intratumoral injections of nanoparticles over a period of 4 weeks. Post-treatment, tumors that received nanoparticle injections were found to be substantially smaller than controls, suggesting that nanoparticle presence significantly increases the efficacy of ultrasonic treatment of solid tumors.

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Kosheleva O, Lai TC, Chan YC, Hsiao M, Ng SL, Chen CH et al. Investigation of nanoparticle-assisted ultrasound therapy for treating implanted breast tumors in mice. In 2017 IEEE 17th International Conference on Nanotechnology, NANO 2017. Institute of Electrical and Electronics Engineers Inc. 2017. p. 672-674. 8117465. (2017 IEEE 17th International Conference on Nanotechnology, NANO 2017). https://doi.org/10.1109/NANO.2017.8117465