Investigation of Bone Growth in Additive-Manufactured Pedicle Screw Implant by Using Ti-6Al-4V and Bioactive Glass Powder Composite

Tu Ngoc Lam, Minh Giam Trinh, Chih Chieh Huang, Pei Ching Kung, Wei Chin Huang, Wei Chang, Lia Amalia, Hsu Hsuan Chin, Nien-Ti Tsou, Shao Ju Shih, San-Yuan Chen, Chun Chieh Wang, Pei I. Tsai, Meng Huang Wu*, E-Wen Huang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In this study, we optimized the geometry and composition of additive-manufactured pedicle screws. Metal powders of titanium-aluminum-vanadium (Ti-6Al-4V) were mixed with reactive glass-ceramic biomaterials of bioactive glass (BG) powders. To optimize the geometry of pedicle screws, we applied a novel numerical approach to proposing the optimal shape of the healing chamber to promote biological healing. We examined the geometry and composition effects of pedicle screw implants on the interfacial autologous bone attachment and bone graft incorporation through in vivo studies. The addition of an optimal amount of BG to Ti-6Al-4V leads to a lower elastic modulus of the ceramic-metal composite material, effectively reducing the stress-shielding effects. Pedicle screw implants with optimal shape design and made of the composite material of Ti-6Al-4V doped with BG fabricated through additive manufacturing exhibit greater osseointegration and a more rapid bone volume fraction during the fracture healing process 120 days after implantation, per in vivo studies.

Original languageEnglish
Article number7438
Pages (from-to)1-13
Number of pages13
JournalInternational journal of molecular sciences
Volume21
Issue number20
DOIs
StatePublished - Oct 2020

Keywords

  • pedicle screw implant
  • additive manufacturing
  • bioactive glass
  • osseointegration
  • stress-shielding effect
  • X-ray tomography
  • PULL-OUT STRENGTH
  • TISSUE DIFFERENTIATION
  • LUMBAR SPINE
  • FIXATION
  • REGENERATION
  • ALLOYS
  • MODEL

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