Integration of fluctuation spectroscopy into a microfluidic platform for novel cellular viscoelastic measurement

Hiroaki Ito*, Chia-Hung Tsai, Makoto Kaneko

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

This paper demonstrates the integration of fluctuation spectroscopy into a microfluidic platform, which enables a novel high-throughput measurement of viscoelastic parameters for μm-sized soft objects such as red blood cells (RBCs) flowing in a microfluidic channel. Utilizing high-speed/precise feedback position control of a RBC inside a narrow microfluidic channel, we successfully performed fluctuation spectroscopy, which is called flicker spectroscopy, sequentially combined with the conventional constriction-passage method. The result shows implicit correlations between mechanical parameters obtained from these two different measurements, providing indications to full information of viscosity and elasticity of a RBC.

Original languageEnglish
Title of host publication2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages137-140
Number of pages4
ISBN (Electronic)9781538647820
DOIs
StatePublished - 24 Apr 2018
Event31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom
Duration: 21 Jan 201825 Jan 2018

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2018-January
ISSN (Print)1084-6999

Conference

Conference31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
CountryUnited Kingdom
CityBelfast
Period21/01/1825/01/18

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