Influence of apatite seeds on the synthesis of calcium phosphate cement

Quanzu Yang*, Tom Troczynski, Dean-Mo LIu

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations


This preliminary study explores the seeding effect (using crystalline hydroxyapatite particles) on the setting time, compressive strength, phase evolution, and microstructure of calcium phosphate cements (CPC) based on monocalcium phosphate monohydrate and calcium hydroxide. Experimental results showed that the setting time varies from 5 to about 30min, as the seed concentration increased from 0 to 20wt%. The compressive strength of CPC increased from 4 to 17MPa, followed by decrease to 12MPa, for the same range of seeds content. The CPC transformed to predominantly apatitic structure within 24h for all the samples, with or without the seeds. However, increase of the seed concentration improved the final crystallinity of the apatite phase, suggesting nucleation and growth effects during precipitation of CPC from the precursor solution. The microstructure of the resulting apatitic cement showed a change from essentially featureless (or glass-like) to thin, elongated plate-like morphology, as seeds concentration increased. Correlation between microstructural evolution and corresponding compressive strength of seeded CPC is investigated.

Original languageEnglish
Pages (from-to)2751-2760
Number of pages10
Issue number13
StatePublished - 15 May 2002


  • Calcium phosphate cement
  • Compressive strength
  • Microstructure
  • Seeding

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