In-situ preparation of poly(propylene fumarate) - Hydroxyapatite composite

Dorna Hakimimehr*, Dean-Mo LIu, Tom Troczynski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


In-situ precipitation of hydroxyapatite (HAp) in the presence of poly(propylene fumarate) (PPF) is investigated. Amorphous calcium phosphate (ACP) precipitates in the presence of the polymer and remains in the amorphous form for a relatively long time, e.g. even after 24 h of coexistence with the mother solution. Our observations suggest that PPF interacts with the surface of the ACP particles and prevents them from transformation to crystalline hydroxyapatite. The PPF polymer seems to be more efficient in hindering the ACP to HAp transformation at higher pH conditions. From spectroscopic observations we hypothesize that the CO bond of the PPF molecules interact with the calcium ion of the ACP particles. In case of low molecular weight PPF this interaction may lead to the incorporation of the polymer within the growing ACP particles.

Original languageEnglish
Pages (from-to)7297-7303
Number of pages7
Issue number35
StatePublished - 1 Dec 2005


  • Amorphous calcium phosphate
  • Composite
  • In-situ synthesis
  • Poly(propylene fumarate)

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