In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging

W. M. Li, San-Yuan Chen*, Dean-Mo LIu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

An amphiphilic gelatin-iron oxide core/calcium phosphate shell (AGIO@CaP-DOX) nanoparticle was successfully synthesized as an efficient anti-cancer drug delivery system, where doxorubicin (DOX) as a model molecule was encapsulated by electrolytic co-deposition during CaP shell formation. The shell of CaP precipitate played a pivotal role, not only in acting as a drug depot, but also in rendering the drug release rate in a highly pH-dependent controlled manner. Together with MR imaging, highly biocompatible drug-carrying CaP shell and efficient cellular internalization, the AGIO@CaP-DOX nanoparticles developed in this study area promising multifunctional nanodevice for nanotherapeutic approaches.

Original languageEnglish
Pages (from-to)5360-5368
Number of pages9
JournalActa Biomaterialia
Volume9
Issue number2
DOIs
StatePublished - 1 Feb 2013

Keywords

  • Amphiphilic gelatin
  • Calcium phosphate
  • Drug release
  • MR imaging
  • pH-sensitivity

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