Improving the evaluation of cell deformability by different channel width in a microfluidic device

Chia-Hung Tsai, Makoto Kaneko, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A method for evaluating red blood cell (RBC) deformability by different channel width in a microfluidic device is proposed. While conventional methods usually have only one test channel to deform RBCs for the evaluation, a design including three test channels with different width is utilized in this work. The proposed design have the advantage of generating a wider range of deformation to each RBC, thus the RBC deformability can be appropriately determined. Experiments on normal RBCs are conducted, and RBC motion through the channels is recorded and analyzed. The velocity drop, the velocity difference between a RBC and flowing fluid, is utilized as an index for the RBC response during deformation. According to the analysis, the relation between the velocity drop and amount of deformation of the RBCs is found nicely fitted with a modified contact model with R2 = 0.91, and the RBC deformability is successfully evaluated as in two deformability constants Cd and ζ.

Original languageEnglish
Title of host publication2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages522-524
Number of pages3
ISBN (Electronic)9781479953325
DOIs
StatePublished - 9 Mar 2014
Event2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014 - Kuala Lumpur, Malaysia
Duration: 12 Nov 201415 Nov 2014

Publication series

Name2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014

Conference

Conference2014 11th International Conference on Ubiquitous Robots and Ambient Intelligence, URAI 2014
CountryMalaysia
CityKuala Lumpur
Period12/11/1415/11/14

Keywords

  • Automation at Micro-Nano Scales
  • Automation in Life Sciences
  • Red Blood Cell

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