Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions

Tung-Kung Wu*, Tsai Ting Wang, Cheng Hsiang Chang, Yuan Ting Liu, Wen Shiang Shie

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

(Chemical Equation Presented) A contact mapping strategy was applied to identify putative amino acid residues that influence the oxidosqualene- lanosterol B-ring cyclization reaction. A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7Y707X mutants, indicating that the Tyr707 residue may play a functional role in stabilizing the chair-boat bicyclic C-8 cation and the lanosteryl C-8/C-9 cation intermediates.

Original languageEnglish
Pages (from-to)4959-4962
Number of pages4
JournalOrganic Letters
Volume10
Issue number21
DOIs
StatePublished - 1 Dec 2008

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