Impact of baseline characteristics on outcomes of carotid artery stenting in acute ischemic stroke patients

Cheng Sheng Yu, Chih Ming Lin, Chi Kuang Liu, Henry Horng Shing Lu*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Carotid artery stenting is an effective treatment for ischemic stroke patients with moderate-to-severe carotid artery stenosis. However, the midterm outcome for patients undergoing this procedure varies considerably with baseline characteristics. To determine the impact of baseline characteristics on outcomes following carotid artery stenting, data from 107 eligible patients with a first episode of ischemic stroke were collected by retrospective chart review. A modified Rankin Scale (mRS) was used to divide patients into two baseline groups, mRS ≤2 and mRS >2. A three-step decision-tree statistical analysis was conducted. After weighting the decision-tree parameters, the following impact hierarchy was obtained: admission low-density lipoprotein, gouty arthritis, chronic kidney disease, ipsilateral common carotid artery resistance index, contralateral ophthalmic artery resistance index, sex, and dyslipidemia. The finite-state machine model demonstrated that, in patients with baseline mRS ≤2, 46% had an improved mRS score at follow-up, whereas 54% had a stable mRS score. In patients with baseline mRS >2, a stable mRS score was observed in 75%, improved score in 23%, and a poorer score in 2%. Admission low-density lipoprotein was the strongest predictive factor influencing poststenting outcome. In addition, our study provides further evidence that carotid artery stenting can be of benefit in first-time ischemic stroke patients with baseline mRS scores >2.

Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalTherapeutics and Clinical Risk Management
Volume12
DOIs
StatePublished - 31 Mar 2016

Keywords

  • Carotid artery stenting
  • Finite-state machine
  • Ischemic stroke
  • Modified rankin scale
  • Resistance index

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