In this paper, we propose an EM based Multiple-Instance learning algorithm for the image classification and indexing. To learn a desired image class, a set of exemplar images are selected by a user. Each example is labeled as conceptual related (positive) or conceptual unrelated (negative) image. A positive image consists of at least one user interested object, and a negative example should not contain any user interested object. By using the proposed learning algorithm, an image classification system can learn the user's preferred image class from the positive and negative examples. We have built a prototype system to retrieve user desired images. The experimental results show that for only a few times of relearning, a user can use the prototype system to retrieve favor images from the WWW over Internet.