Identifying cancer highly-expressed membrane receptors for targeted drug delivery

Wei Chih Huang, Feng Mao Lin, Tzu Hao Chang, Kuang-Wen Liao, Hsien Da Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Currently, the accompanying side effects of anti-cancer drugs owing to incorrect delivery to normal tissues should be reduced. We present a database (MRTDD) with identified cancer highly-expressed membrane receptors (CHMRs) which can be used in targeted drug delivery. To evaluate the probability of occurrence of incorrect delivery, we calculate tissue index for each CHMR and expect to identify good candidates. The information provided includes: (1) genomic annotations; (2) gene expression profiles of membrane receptors in cancer tissue vs. corresponding normal tissue, normal tissues of body and cancer cell-lines; (3) available antibody services of manufacturers. MRTDD is available at http://mrtdd.mbc.nctu.edu.tw/.

Original languageEnglish
Pages (from-to)192-209
Number of pages18
JournalInternational Journal of Bioinformatics Research and Applications
Volume8
Issue number3-4
DOIs
StatePublished - 1 Sep 2012

Keywords

  • Bioinformatics
  • Membrane receptor
  • Microarray analysis
  • Targeted drug delivery

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