Identification of functional modules that correlate with phenotypic difference: The influence of network topology

Jui-Hung Hung, Troy W. Whitfield, Tun Hsiang Yang, Zhenjun Hu, Zhiping Weng*, Charles DeLisi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis.

Original languageEnglish
Article numberr23
JournalGenome Biology
Volume11
Issue number2
DOIs
StatePublished - 26 Feb 2010

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