Hypericin-mediated selective photomodification of connective tissues

V. Hovhannisyan, A. Hovhannisyan, V. Ghukasyan, H. W. Guo, Hung Ming Lin, Shean-Jen Chen, Yang Fang Chen, Chen Yuan Dong

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Hypericin (Hyp) has received attention due to its high phototoxicity against viruses and anti-tumor photoactivity. Using two-photon imaging, we demonstrated that Hyp induced photosensitized modification of collagen fibers in native tissues. Dynamics of photo-processes was monitored by time-lapse multiphoton imaging. We showed that Hyp-mediated processes in collagen tissues may be used for the selective modification of collagen fibers.

Original languageEnglish
Title of host publicationPhotonics in Dermatology and Plastic Surgery
EditorsHaishan Zeng, Bernard Choi
ISBN (Electronic)9781510605152
StatePublished - 1 Jan 2017
EventPhotonics in Dermatology and Plastic Surgery - San Francisco, United States
Duration: 28 Jan 201729 Jan 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotonics in Dermatology and Plastic Surgery
CountryUnited States
CitySan Francisco


  • Hypericin
  • SHG
  • biological imaging
  • collagen
  • multiphoton microscopy

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