Hydroxymethylation of organic halides. Evaluation of a catalytic system involving a fluorous tin hydride reagent for radical carbonylation

Ilhyong Ryu*, Tatsuro Niguma, Satoshi Minakata, Mitsuo Komatsu, Sabine Hadida, Dennis P. Curran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Hydroxymethylation of organic halides 2 using a catalytic amount of fluorous tin hydride 1, CO, and NaBH 3 CN as a reducing agent, proceeded smoothly to give one-carbon homologated alcohols 5 in good yields. Three phase workup (water-dichloromethane-perfluorohexane) was conveniently performed for the separation of 1 and 5.

Original languageEnglish
Pages (from-to)7883-7886
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number45
DOIs
StatePublished - 10 Nov 1997

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