Hybridization sensing by electrical enhancement with nanoparticles in nanogap

Chun Chi Chen*, Fu-Hsiang Ko, Edward Yi Chang, Feng Chih Chang, Shiao Wei Kuo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this work, the monolayer of gold nanoparticles within 72 nm gap has been proposed to function as a DNA sensor. The authors suggest that the nanoparticles in the nanogap could act as hopping sites which amplify the conductance of hybridized DNA strands. The conductance amplification between single strand and hybridized DNAs through gold nanoparticles is observed. Various concentrations of capture and target DNA are discussed for optimal hybridization sensing purpose. With the help of 1 nM capture DNAs, this sensor is able to analyze target DNA sequences at very low concentration of 1 fM. Furthermore, by means of adjusting the denature temperature to 60 °C, even single mismatch hybridization could be discriminated.

Original languageEnglish
Pages (from-to)2572-2577
Number of pages6
JournalJournal of Vacuum Science and Technology B: Microelectronics and Nanometer Structures
Volume26
Issue number6
DOIs
StatePublished - 11 Dec 2008

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