Human tissue kallikreins as prognostic biomarkers and as potential targets for anticancer therapy

Wun Shaing W. Chang*, Ruey Hwang Chou, Cheng-Wen Wu, Jang Yang Chang

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The tissue kallikrein family represents the largest cluster of contiguous proteinase genes in the entire human genome. Its 15 members are expressed primarily in a tissue-specific manner, but can also be detected in biological fluids such as serum and seminal plasma. The mature active tissue kallikreins play vital roles in numerous physiological and pathological processes, in which they are able to function individually or in cascade pathway(s). Their genetic polymorphisms, alternative splicings and aberrant amounts of transcripts and/or proteins are often correlated with increased cancer risk, thus providing a sensible application for the use of tissue kallikreins as diagnostic, prognostic and predictive tumour markers. In this review, an updated overview of scientific research and patents regarding the functional features and clinical indications of tissue kallikreins in neoplastic diseases is provided.

Original languageEnglish
Pages (from-to)1227-1240
Number of pages14
JournalExpert Opinion on Therapeutic Patents
Volume17
Issue number10
DOIs
StatePublished - 1 Oct 2007

Keywords

  • Kallikrein
  • Metastasis
  • Prognosis
  • Proteinase
  • Proteolytic enzyme
  • Serine proteinase
  • Tumour marker

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