Host-guest interaction of rotaxane assembly through selective detection of ferric ion: Insight into hemin sensing and switching with sodium ascorbate

Tarun Shukla, Atul Kumar Dwivedi, Reguram Arumugaperumal, Chien Min Lin, San-Yuan Chen, Hong-Cheu Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A mechanically interlocked host rotaxane was synthesized by incorporation of tetraphenylethylene and phenanthroimidazole units in the axle to exhibit significant emission bands and demonstrate host-guest interactions via its topologically constrained cavity, and thus to induce a significant and selective fluorescence quenching of rotaxane towards ferric ion (Fe3+). The quenching efficiencies of rotaxane with both ferric ion (Fe3+) and bio-molecular Hemin (containing ferric ion) were investigated to compare the sensitivities of rotaxane for ferric ion and bio-molecular Hemin. The present study could probe host-guest interactions of rotaxane with ferric ion (Fe3+) and Hemin as well as monitoring the biological conversion of Hemin to Heme in presence of sodium ascorbate (as a reducing agent), where the reduced non-toxic Heme could be generated from the toxic form of Hemin.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalDyes and Pigments
Volume131
DOIs
StatePublished - 1 Aug 2016

Keywords

  • Aggregation induced emission
  • Ferric ion
  • Host-guest interaction
  • Rotaxane
  • Tetraphenylethylene

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