Highly sensitive surface-enhanced raman nano-probing for direct proteomic profiling

Yi-Chun Chen*, Zhida Xu, Logan Liu, Jean Philippe Coppe

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Nanocone structures were fabricated by a unique etching-passivation process as the substrates for Surface Enhanced Raman Spectroscopy (SERS). This novel nanostructured SERS substrate allowed reaching unprecedented detection limits (fM of Rhodamin6G; pM of crude peptides), and supported the detection of subtle changes in peptide probe sequences, such as single amino acid phosphosphorylation or mutation. Thus, surface-conjugated peptides could be used as highly potent biological nano-sensors for sensitive profiling of specific protein-mediated chemical changes on nano-sensing probes. We hope such kinase-enzyme activity screening array device and technology will advance all aspects of Life Sciences, and potentially be applied to environment monitoring.

Original languageEnglish
Title of host publicationIEEE Sensors 2010 Conference, SENSORS 2010
Pages2295-2298
Number of pages4
DOIs
StatePublished - 1 Dec 2010
Event9th IEEE Sensors Conference 2010, SENSORS 2010 - Waikoloa, HI, United States
Duration: 1 Nov 20104 Nov 2010

Publication series

NameProceedings of IEEE Sensors

Conference

Conference9th IEEE Sensors Conference 2010, SENSORS 2010
CountryUnited States
CityWaikoloa, HI
Period1/11/104/11/10

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    Chen, Y-C., Xu, Z., Liu, L., & Coppe, J. P. (2010). Highly sensitive surface-enhanced raman nano-probing for direct proteomic profiling. In IEEE Sensors 2010 Conference, SENSORS 2010 (pp. 2295-2298). [5690802] (Proceedings of IEEE Sensors). https://doi.org/10.1109/ICSENS.2010.5690802