Highly sensitive ammonia sensor with organic vertical nanojunctions for noninvasive detection of hepatic injury

Ming Zhi Dai, Yi Lo Lin, Hung Cheng Lin, Hsiao-Wen Zan*, Kai Ting Chang, Hsin-Fei Meng, Jiunn Wang Liao, May Jywan Tsai, Henrich Cheng

*Corresponding author for this work

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

We successfully demonstrate the first solid-state sensor to have reliable responses to breath ammonia of rat. For thioacetamide (TAA)-induced hepatopathy rats, we observe that the proposed sensor can detect liver that undergoes acute-moderate hepatopathy with a p-value less than 0.05. The proposed sensor is an organic diode with vertical nanojunctions produced by using low-cost colloidal lithography. Its simple structure and low production cost facilitates the development of point-of-care technology. We also anticipate that the study is a starting point for investigating sophisticated breath-ammonia-related disease models.

Original languageEnglish
Pages (from-to)3110-3117
Number of pages8
JournalAnalytical Chemistry
Volume85
Issue number6
DOIs
StatePublished - 19 Mar 2013

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