High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki-Heck reaction in ionic liquids, in situ, using a novel array reactor

Md Taifur Rahman, Takahide Fukuyama, Ilhyong Ryu, Kanae Suzuki, Koichi Yonemura, Philip F. Hughes, Kiyoshi Nokihara*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The parallel Sonogashira coupling reaction was carried out under copper-free condition by integrating the advantages of ionic liquids as the reaction media followed by the simultaneous-multiple Mizoroki-Heck reaction in situ by the use of a novel array reactor (SynArray-24). The device provides rapid evaluation of reactions in a short period.

Original languageEnglish
Pages (from-to)2703-2706
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number16
DOIs
StatePublished - 17 Apr 2006

Keywords

  • Array reactor
  • Combinatorial solution synthesis
  • Mizoroki-Heck reaction
  • Sonogashira reaction

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