An efficient VLSI pipelined processor design for high-speed lossless compression based on "Rice algorithm" has been developed to meet the increasing strong demands on high-volume/high-speed image data communication and storage. The Rice algorithm is an adaptive lossless coding scheme that provides near-optimal performance over a broad range of data entropies. The Rice algorithm is also an efficiently implementable scheme for VLSI realization. A VLSI pipelined architecture was developed to allow compact implementation of a single-chip VLSI compressor. This lossless compressor is named PSI14,K+ since it implements an advanced version of the Rice's universal noiseless coding method called PSI14,K+. The chip layout was generated for a 1.0- micron CMOS technology. It occupies a compact chip area of 5.1 × 5.3 mm2, with 49,000 transistors, 57 input/output pads, and 6 power/ground pads. The total power dissipation is 0.4 watts at the 40 MHz system clock with a 50% switching duty cycle. This compressor chip is mounted in a 68-pin pin-grid-array package. It can operate up to 40 Mpixels/sec. The potential applications of the proposed lossless compressor include database management systems, scientific instruments, CAE workstations, desktop computing machines, and the data systems that require highspeed compression without fidelity loss.