High-level synthesis for micro-electrode-dot-array digital microfluidic biochips

Zipeng Li, Kelvin Yi Tse Lai, Po Hsien Yu, Tsung Yi Ho, Krishnendu Chakrabarty, Chen-Yi Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

33 Scopus citations


A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. However, today's DMFBs suffer from several limitations: (i) constraints on droplet size and the inability to vary droplet volume in a fine-grained manner; (ii) the lack of integrated sensors for real-time detection; (iii) the need for special fabrication processes and reliability/yield concerns. To overcome the above problems, DMFBs based on a micro-electrode-dot-array (MEDA) architecture have recently been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions cannot be utilized for MEDA-based biochips. We present the first biochip synthesis approach that can be used for MEDA. The proposed synthesis method targets operation scheduling, module placement, routing of droplets of various sizes, and diagonal movement of droplets in a two-dimensional array. Simulation results using benchmarks and experimental results using a fabricated MEDA biochip demonstrate the effectiveness of the proposed co-optimization technique.

Original languageEnglish
Title of host publicationProceedings of the 53rd Annual Design Automation Conference, DAC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781450342360
StatePublished - 5 Jun 2016
Event53rd Annual ACM IEEE Design Automation Conference, DAC 2016 - Austin, United States
Duration: 5 Jun 20169 Jun 2016

Publication series

NameProceedings - Design Automation Conference
ISSN (Print)0738-100X


Conference53rd Annual ACM IEEE Design Automation Conference, DAC 2016
CountryUnited States

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