Healing Pattern Analysis for Dental Implants Using the Mechano-Regulatory Tissue Differentiation Model

Ming-Jun Li, Pei-Ching Kung, Yuan-Wei Chang, Nien-Ti Tsou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


(1) Background: Our aim is to reveal the influence of the geometry designs on biophysical stimuli and healing patterns. The design guidelines for dental implants can then be provided. (2) Methods: A two-dimensional axisymmetric finite element model was developed based on mechano-regulatory algorithm. The history of tissue differentiation around eight selected implants can be predicted. The performance of the implants was evaluated by bone area (BA), bone-implant contact (BIC); (3) Results: The predicted healing patterns have very good agreement with the experimental observation. Many features observed in literature, such as soft tissues covering on the bone-implant interface; crestal bone loss; the location of bone resorption bumps, were reproduced by the model and explained by analyzing the solid and fluid biophysical stimuli and (4) Conclusions: The results suggested the suitable depth, the steeper slope of the upper flanks, and flat roots of healing chambers can improve the bone ingrowth and osseointegration. The mechanism related to solid and fluid biophysical stimuli were revealed. In addition, the model developed here is efficient, accurate and ready to extend to any geometry of dental implants. It has potential to be used as a clinical application for instant prediction/evaluation of the performance of dental implants.

Original languageEnglish
Article number9205
Number of pages13
JournalInternational Journal Of Molecular Sciences
Issue number23
StatePublished - Dec 2020


  • dental implants
  • mechano-regulatory
  • tissue differentiation
  • healing chamber

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