Growth of gold nanowires on flexible substrate for highly sensitive biosensing: Detection of thrombin as an example

Yu Liang Chen, Chi Young Lee, Hsin-Tien Chiu*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

We demonstrated a facile fabrication of high density Au nanostructures including nanothorns (NTs), nanocorals (NCs), nanoslices (NSs), and nanowires (NWs) which were electrochemically grown on flexible plastic substrates of polyethylene terephthalate (PET). A thrombin-binding aptamer was immobilized on the surfaces of the Au nanostructures to form highly sensitive electrochemical impedance spectroscopic (EIS) biosensors for thrombin recognition. The binding of thrombin to the aptamer sequence was monitored by EIS in the presence of [Fe(CN)6]3-/4-(aq). The protein (1-50 pM) was detected linearly by the Au nanostructures. Among them, the Au NWs exhibited excellent thrombin detection performances. The biosensor provided high sensitivity, selectivity, and stability due to its high surface area.

Original languageEnglish
Pages (from-to)186-193
Number of pages8
JournalJournal of Materials Chemistry B
Volume1
Issue number2
DOIs
StatePublished - 14 Jan 2013

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