Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging

Wen Shuo Kuo*, Hua Han Chen, Shih Yao Chen, Chia Yuan Chang, Pei Chi Chen, Yung I. Hou, Yu Ting Shao, Hui Fang Kao, Chih Li Lilian Hsu, Yi Chun Chen, Shean-Jen Chen, Shang Rung Wu, Jiu Yao Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalBiomaterials
Volume120
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Antimicrobial
  • Contrast probe
  • Nitrogen-doped graphene quantum dot
  • Photodynamic therapy
  • Photostability
  • Reactive oxygen species

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