Glycosylation chemistry of 3-deoxy-D-manno-Oct-2-ulosonic acid (Kdo) donors

Tapan Kumar Pradhan, Kwok-Kong Mong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

3-Deoxy-D-manno-Oct-2-ulosonic acid (Kdo)-containing oligosaccharides are a conserved carbohydrate component in lipopolysaccharides (LPSs) of the outer membrane of Gram-negative bacteria, and they are also present in capsular polysaccharides (CPSs) of bacteria and plant cells. The association of the bacterial LPS with the pathophysiology of bacterial infection have long been recognized. Structure pathophysiology studies of bacterial infection need to use pure and homogeneous LPS fragments. Such a requirement can be fulfilled by the synthesis of Kdo glycosides and related Kdo oligosaccharide conjugates. This article provides an overview of the glycosylation chemistries of the synthesis of Kdo α-/β-glycosides, oligosaccharides with Kdo units such as LPS core oligosaccharides, and lipid A derivatives.

Original languageEnglish
Pages (from-to)285-296
Number of pages12
JournalIsrael Journal of Chemistry
Volume55
Issue number3-4
DOIs
StatePublished - 1 Apr 2015

Keywords

  • 3-deoxy- D -manno-oct-2-ulosonic acid
  • capsular polysaccharides
  • glycosylation
  • isomers
  • lipopolysaccharides

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