3-Deoxy-D-manno-Oct-2-ulosonic acid (Kdo)-containing oligosaccharides are a conserved carbohydrate component in lipopolysaccharides (LPSs) of the outer membrane of Gram-negative bacteria, and they are also present in capsular polysaccharides (CPSs) of bacteria and plant cells. The association of the bacterial LPS with the pathophysiology of bacterial infection have long been recognized. Structure pathophysiology studies of bacterial infection need to use pure and homogeneous LPS fragments. Such a requirement can be fulfilled by the synthesis of Kdo glycosides and related Kdo oligosaccharide conjugates. This article provides an overview of the glycosylation chemistries of the synthesis of Kdo α-/β-glycosides, oligosaccharides with Kdo units such as LPS core oligosaccharides, and lipid A derivatives.
- 3-deoxy- D -manno-oct-2-ulosonic acid
- capsular polysaccharides