Genotype analysis based on intergenic spacer 1 sequences of Trichosporon asahii collected in Taiwan

Yun-Liang Yang, Yi Wen Liu, Hui-Ting Chen, Moan-Shane Tsai, Wen-Li Chu, Hsiu-Jung Lo

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13 Scopus citations

Abstract

Among 32 Trichosporon asahii isolates collected in four rounds of the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) studies, conducted in 1999, 2002, 2006, and 2010, five different intergenic spacer 1 (IGS1) genotypes were detected. Genotype 1 was the most common (43.8%), followed by genotypes 3 (28.1%), 7 (12.5%), 5 (9.4%), and 4 (6.3%). Interestingly, genotype 7 was more prevalent in Taiwan than in other areas (P = 0.01); while we did not find a significant association between IGS1 genotype and susceptibility to antifungal drugs, we did note that the majority of isolates of T. asahii were susceptible to both fluconazole and voriconazole, consistent with previous reports. A higher proportion of isolates (P = 0.05) collected in 2010 (4/12, 33.3%) had high amphotericin B MICs (>= 2 mg/l) than those collected in the previous three TSARYs (1/21, 5%). Hence, the new data of genotypes and drug susceptibilities in the present study may contribute to the epidemiology of T. asahii
Original languageEnglish
Pages (from-to)880-883
Number of pages4
JournalMedical Mycology
Volume51
Issue number8
DOIs
StatePublished - Nov 2013

Keywords

  • Trichosporon; intergenic spacer 1; genotypes; IGS1; Trichosporon asahii
  • AMPHOTERICIN-B; MOLECULAR-IDENTIFICATION; ANTIFUNGAL SUSCEPTIBILITIES; CANDIDA; FLUCONAZOLE; YEAST; COLONIZATION; EPIDEMIOLOGY; INFECTIONS; RESISTANCE

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