Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways

Arne Weiberg, Ming Wang, Feng Mao Lin, Hongwei Zhao, Zhihong Zhang, Isgouhi Kaloshian, Hsien-Da Huang, Hailing Jin

Research output: Contribution to journalArticlepeer-review

463 Scopus citations

Abstract

Botrytis cinerea, the causative agent of gray mold disease, is an aggressive fungal pathogen that infects more than 200 plant species. Here, we show that some B. cinerea small RNAs (Bc-sRNAs) can silence Arabidopsis and tomato genes involved in immunity. These Bc-sRNAs hijack the host RNA interference (RNAi) machinery by binding to Arabidopsis Argonaute 1 (AGO1) and selectively silencing host immunity genes. The Arabidopsis ago1 mutant exhibits reduced susceptibility to B. cinerea, and the B. cinerea dcl1 dcl2 double mutant that can no longer produce these Bc-sRNAs displays reduced pathogenicity on Arabidopsis and tomato. Thus, this fungal pathogen transfers "virulent" sRNA effectors into host plant cells to suppress host immunity and achieve infection, which demonstrates a naturally occurring cross-kingdom RNAi as an advanced virulence mechanism.
Original languageEnglish
Pages (from-to) 118-123
Number of pages6
JournalScience
Volume342
Issue number6154
DOIs
StatePublished - 4 Oct 2013

Keywords

  • PATHOGENIC FUNGUS; GENE; EFFECTORS; MICRORNAS; DIVERSE; ROLES; CELLS

Fingerprint Dive into the research topics of 'Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways'. Together they form a unique fingerprint.

Cite this