Functional gold nanoparticle-based antibacterial agents for nosocomial and antibiotic-resistant bacteria

Yen Ling Kuo, Sin Ge Wang, Ching Yi Wu, Kai Chieh Lee, Chan Jung Jao, Shiu Huey Chou, Yu-Chie Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Aim: Medical treatments for bacterial-infections have become challenging because of the emergence of antibiotic-resistant bacterial strains. Thus, new therapeutics and antibiotics must be developed. Materials & methods: Arginine and tryptophan can target negatively-charged bacteria and penetrate bacterial cell membrane, respectively. Synthetic-peptides containing arginine, tryptophan and cysteine termini, in other words, (DVFLG)2REEW4C and (DVFLG)2REEW2C, as starting materials were mixed with aqueous tetrachloroauric acid to generate peptide-immobilized gold nanoparticles (i.e., [DVFLG]2REEW4C-AuNPs and [DVFLG]2REEW2C-AuNPs) through one-pot reactions. Results & discussion: The peptide immobilized AuNPs exhibit targeting capacity and antibacterial activity. Furthermore, (DVFLG)2REEW4C-AuNPs immobilized with a higher number of tryptophan molecules possess more effective antibacterial capacity than (DVFLG)2REEW2C-AuNPs. Nevertheless, they are not harmful for animal cells. The feasibility of using the peptide-AuNPs to inhibit the cell growth of bacterium-infected macrophages was demonstrated. Conclusion: These results suggested that the proposed antibacterial AuNPs are effective antibacterial agents for Staphylococci, Enterococci and antibiotic-resistant bacterial strains. </inline-graphic.

Original languageEnglish
Pages (from-to)2497-2510
Number of pages14
JournalNanomedicine
Volume11
Issue number19
DOIs
StatePublished - 1 Oct 2016

Keywords

  • antibacterial peptides
  • antibiotic-resistant bacteria
  • antibiotics
  • Au NPs
  • Enterococcus faecalis
  • Enterococcus faecium
  • macrophages
  • MRSA
  • Staphylococcus aureus
  • VRE

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