E-healthcare games are a new patient care tool for providing fun, on-line monitoring enabled lifestyle, and a way for redefining traditional doctor-patient relationship. In this work, we demonstrate the use of intelligent sensors to capture patient behaviors for home healthcare. We design a new e-healthcare game user interface, iCube, for monitoring and recording patient activities. The iCube is a 3D game which has six display panels on the surfaces of a 3D cube embedded with a zigbee interface and some sensors for behavior monitoring. To prove its concept, we implement a Spot the Difference game. When a player is playing the game, the iCube can capture the player's hand shaking, rolling response, and visual capability. Those collected data are then sent to a database for spotting the progress/difference of the player over a long period time.