Formylnitroenamines: Useful building blocks for nitrated pyridones and aminopyridines with functional groups

Yumi Nakaike, Daisuke Hayashi, Nagatoshi Nishiwaki*, Yoshito Tobe, Masahiro Ariga

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

β-Formyl-β-nitroenamines 1 possess both an electrophilic formyl group and a nucleophilic amino group and, therefore, serve as C3N1 building blocks having a nitro group to afford nitropyridones and aminonitropyridines with a functional group at the 3-position. Upon treatment with malonic acid derivatives or β-keto esters, nitropyridones were obtained, whereas reactions with functionalized acetonitriles afford aminonitropyridines, via a formal transfer of an alkyl group from the ring nitrogen to the imino group. These procedures provide practical and useful methods for preparation of heterocycles with a nitro group.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume7
Issue number2
DOIs
StatePublished - 2 Jan 2009

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