Focused microwave-assisted parallel synthesis of bis-benzimidazoles

Mei Jung Lin, Chung-Ming Sun*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Combinatorial parallel synthesis of bis-benzimidazoles by focused (mono-modal) microwave irradiation is described. Polymer immobilized o-phenylenediamines as a versatile template was synthesized under microwave irradiation. The resulting PEG bound diamines was N-acylated with 4-fluoro-3-nitrobenzoic acid selectively in primary aromatic amino moiety. Nucleophilic aromatic substitution of the amide obtained was performed with different amines then cyclized to benzimidazole in acidic condition. Successive reduction, cyclization with various aldehydes yielded 5-(benzimidazol-2-yl) benzimidazoles. The desired products were released from the polymer support to afford the tri-substituted bis-benzimidazoles in good yields and purity.

Original languageEnglish
Pages (from-to)663-666
Number of pages4
Issue number4
StatePublished - 9 Mar 2004


  • Bis-benzimidazole
  • Combinatorial chemistry
  • Liquid-phase method
  • Scaffold
  • Solid-phase method

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