Fluorescent B-10 embedded nanodiamonds as B-10 delivery agent for boron neutron capture therapy

Bo-Rong Lin, Srinivasu Kunuku, Tzung-Yuang Chen, Yu Jen Chang, Li Chuan Liao, Chien-Hsu Chen, Tung-Yuan Hsiao, Hung-Kai Yu, Huan Niu, Chien-Ping Lee

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Abstract

Boron neutron capture therapy is a potentially powerful anti-cancer treatment, the success of which depends heavily on the boron delivery agent. Enabling the real-time tracing of delivery agents as they move through the body is crucial to the further development of boron neutron capture therapy. In this study, we fabricate fluorescent B-10 embedded nanodiamonds using physical ion implantation in conjunction with a two-step annealing process. Fluorescent B-10 embedded nanodiamonds perform well in cell viability test. The red fluorescence of the B-10 embedded nanodiamonds allows their use in fluorescence microscopy and in vivo imaging systems, thereby making it possible to conduct tracking in real time. The proposed fluorescent B-10 embedded nanodiamonds, combining optical visibility and B-10 transport capability, might be a promising boron delivery agent suitable for a wide range of biomedical applications.
Original languageEnglish
Article number26LT01
JournalJournal of Physics D: Applied Physics
Volume52
Issue number26
DOIs
StatePublished - 26 Jun 2019

Keywords

  • nanodiamonds; ion implantation; boron neutron capture therapy; boron delivery agent; fluorescence; IVIS
  • DIAGNOSED GLIOBLASTOMA-MULTIFORME; CANCER; RADIOTHERAPY

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    Lin, B-R., Kunuku, S., Chen, T-Y., Chang, Y. J., Liao, L. C., Chen, C-H., Hsiao, T-Y., Yu, H-K., Niu, H., & Lee, C-P. (2019). Fluorescent B-10 embedded nanodiamonds as B-10 delivery agent for boron neutron capture therapy. Journal of Physics D: Applied Physics, 52(26), [26LT01]. https://doi.org/10.1088/1361-6463/ab188c