Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions

Hui Hsin Lu, Chii Wann Lin*, Tzu-Chien Hsiao, Chih Kung Lee, Su Ming Hsu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We employed atomic force microscopy (AFM) with bias control to fabricate oxided nanopatterns on silicon surface with feature size down to 50nm. The relationship of silicon dioxide nanopatterns against humidity was studied and then the optimal parameter was used to make oxide nanoarry for interaction of biotin and streptavidin. The scanning function of AFM was utilized to verify the different height of biomolecules. According to our experimental results, using nano biochip of silicon dioxide can decrease the monitoring scale to nanometer and can be the nano-platform for monitoring the behavior of biomolecular interaction. We anticipate mimicking the correlation of single molecular behavior and an array of biomolecular behavior to understand the coincidence of them.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
DOIs
StatePublished - 21 Apr 2008
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V - San Jose, CA, United States
Duration: 21 Jan 200823 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6865
ISSN (Print)1605-7422

Conference

ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications V
CountryUnited States
CitySan Jose, CA
Period21/01/0823/01/08

Keywords

  • Electrochemical atomic force microscopy
  • Nano biochip
  • Silicon dioxide nanopatterns

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    Lu, H. H., Lin, C. W., Hsiao, T-C., Lee, C. K., & Hsu, S. M. (2008). Fabrication of silicon dioxide nano array for bio-mimicking of molecular interactions. In Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications V [68650D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6865). https://doi.org/10.1117/12.762919