Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation

Hsiao Wei Wang, Chung-Wei Cheng, Ching Wen Li, Han Wei Chang, Ping Han Wu, Gou Jen Wang*

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

One of the persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system could be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds of polylactic-co-glycolic acid (PLGA). This novel scaffold facilitates implementation of the conventional cell seeding process. The progress of cell growth can be observed in vitro by optical microscopy. The problems of becoming milky or completely opaque with the conventional PLGA scaffold after cell seeding can be resolved. In this study, PLGA microvessel scaffolds consisting of 47 μm × 80 μm pillared branches were produced. Results of cell culturing of bovine endothelial cells demonstrate that the cells adhere well and grow to surround each branch of the proposed pillared microvessel networks.

Original languageEnglish
Pages (from-to)1865-1873
Number of pages9
JournalInternational Journal of Nanomedicine
Volume7
DOIs
StatePublished - 5 Dec 2012

Keywords

  • Bovine endothelial cells
  • Femtosecond laser ablation
  • Pillared microvessel scaffold
  • Polylactic-co-glycolic acid

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