Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation

Hsiao Wei Wang, Ching Wen Li, Chung-Wei Cheng, Gou Jen Wang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

One of the continuing, persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system can be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds in PLGA. This novel scaffold enable the conventional cell seeding process to be implemented and the progress of cell growth to be observed in vitro by an optical microscopy. Hence, the milky and completely opaque problems of the conventional PLGA scaffold after cell seeding can be resolved. Currently, PLGA microvessel scaffolds consisting of 30μm×200μm pillared branches have been produced. Cell cultural results of BECs demonstrate that cells can well adhere and grow surrounding each branch of the proposed pillared microvessel networks. The promising results reveal that an artificial microvessel networks for tissue engineering can be completely realized.

Original languageEnglish
Title of host publicationASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
Pages33-39
Number of pages7
DOIs
StatePublished - 1 Dec 2011
EventASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011 - Washington, DC, United States
Duration: 28 Aug 201131 Aug 2011

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume7

Conference

ConferenceASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2011
CountryUnited States
CityWashington, DC
Period28/08/1131/08/11

Fingerprint Dive into the research topics of 'Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation'. Together they form a unique fingerprint.

Cite this