Exploring the stochastic dynamics of correlated movement of receptor proteins in plasma membranes in vivo

Jung Y. Huang, Chien Y. Lin

Research output: Contribution to journalArticlepeer-review

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Abstract

Ligand-induced receptor dimerization plays a crucial role in the signaling process of living cells. In this study, we developed a theoretical model and performed single-molecule tracking to explore the correlated diffusion processes of liganded epidermal growth factor receptors prior to dimer formation. We disclosed that both an attractive potential between liganded receptor proteins in proximity and correlated fluctuations in the local environments of the proteins play an important role to produce the observed correlated movement of the receptors. This result can serve as the foundation to shed light on the way in which receptor functions are regulated in plasma membranes in vivo.

Original languageEnglish
Article number225101
JournalJournal of Chemical Physics
Volume143
Issue number22
DOIs
StatePublished - 14 Dec 2015

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