Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: Solid-phase synthesis of sulfonamides and ureas

Tsai Wen Chung, Chih Hau Chen, Chu Chung Lin, Hsien Jen Wu, Chung-Ming Sun*, Wen-Sheng Chung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed.

Original languageEnglish
Pages (from-to)463-476
Number of pages14
JournalMolecular Diversity
Volume16
Issue number3
DOIs
StatePublished - 1 Aug 2012

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