Enhancing early stage of hepatocellular carcinoma: Does correlate to MicroRNA 122 and miR196a interaction?

Hendra Susanto*, Chih Hong Wang, Aulanni'Am Aulanni'Am, Adeodatus Yuda Handaya

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hepatocellular carcinoma (HCC) is a representative of almost 85-90% of liver cancer in the recent global incidence. HCC is the second leading cause of mortality in subjects with cancer. The higher prevalence of this disease significantly increased in the Asia Pacific region in the last decades. Fatty liver (steatosis) linked cirrhosis showed a substantial contribution to the acceleration of HCC in patients. Importantly, another primary inducer of fatty liver, a short non-coding RNA miR-122, and miR196a are the essential miRNAs that predicted enhance the progression of HCC in the younger age. However, the lack of information about HCC related liver-derived hormone and miRNA remains. This study was conducted by using miR-122+/--miR-196 (+) to generate miR-122-/--miR 196 (+). In the current data, the significant morphological alteration of the liver with the early formation of nodule-like in the surface area was observed. Based on the histological section, the chronic portal inflammation also occurred in the liver of this double genetic modification mouse model. In summary, the interaction of miR-122 and miR196a may accelerate liver fibrosis due to chronic inflammation within the liver progress to cirrhosis in the early stage of hepatocellular carcinoma.

Original languageEnglish
Title of host publicationInternational Conference on Biology and Applied Science, ICOBAS 2019
Editors Romaidi, Didik Wahyudi, Retno Novvitasari Hery Daryono, Eriyanto Yusnawan, Akira Kikuchi
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418608
DOIs
StatePublished - 3 Jul 2019
EventInternational Conference on Biology and Applied Science 2019, ICOBAS 2019 - Malang, Indonesia
Duration: 13 Mar 201914 Mar 2019

Publication series

NameAIP Conference Proceedings
Volume2120
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

ConferenceInternational Conference on Biology and Applied Science 2019, ICOBAS 2019
CountryIndonesia
CityMalang
Period13/03/1914/03/19

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    Susanto, H., Wang, C. H., Aulanni'Am, AA., & Handaya, A. Y. (2019). Enhancing early stage of hepatocellular carcinoma: Does correlate to MicroRNA 122 and miR196a interaction? In Romaidi, D. Wahyudi, R. N. H. Daryono, E. Yusnawan, & A. Kikuchi (Eds.), International Conference on Biology and Applied Science, ICOBAS 2019 [070021] (AIP Conference Proceedings; Vol. 2120). American Institute of Physics Inc.. https://doi.org/10.1063/1.5115738