Enhancement of detection by selective modification of silicon nanobelt field-effect transistors via localized Joule heating

Hao Heng Liu, Tzung Han Lin, Jeng-Tzong Sheu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We utilized localized Joule heating to ablate methoxy-poly (ethylene-glycol)-silane (mPEG-sil) modified on the p- region of an n+-p--n+ silicon nanobelt field-effect transistor (SNFET). SNFETs with selective modifications of 3- aminopropyltrimethoxysilane (APTMS) and NHS-biotin on the ablated region exhibited a faster sensing response rate and a higher sensitivity in real-time detection of Streptavidin (SA). Characterization of the ablated region via lateral force microscopy and the fluorescence image show that the ablation region occurs only in the p- region near the drain side and is believed to be a result of the impact ionization mechanism during Joule heating. Moreover, a bias of 20 V pulse voltage for 1 ms successfully ablates mPEG-sil and reduces the device off leakage current by 1 order after Joule heating. However, Joule heating with a pulse voltage larger than 20 V (1 ms) yielded an increase of device off leakage owing to damage to gate dielectrics during Joule heating. A comparison of real-time detection of SA between selectively and non-selectively modified chips shows that selectively modified ones exhibit a better limit of detection (LOD) that is one order lower than non-selectively modified ones, and a sensing response rate twice as fast as the non-selectively modified one for every target concentration.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume192
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Localized Joule heating
  • Methoxy-poly (ethylene-glycol)-silane
  • Selective modification
  • Silicon nanobelt field-effect transistor
  • Streptavidin

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