Enhancement of cell growth on honeycomb-structured polylactide surface using atmospheric-pressure plasma jet modification

Kuang Yao Cheng, Chia Hsing Chang, Yi Wei Yang, Guo Chun Liao, Chih Tung Liu, Jong-Shinn Wu*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In this paper, we compare the cell growth results of NIH-3T3 and Neuro-2A cells over 72 h on flat and honeycomb structured PLA films without and with a two-step atmospheric-pressure nitrogen-based plasma jet treatment. We developed a fabrication system used for forming of a uniform honeycomb structure on PLA surface, which can produce two different pore sizes, 3–4 μm and 7–8 μm, of honeycomb pattern. We applied a previously developed nitrogen-based atmospheric-pressure dielectric barrier discharge (DBD) jet system to treat the PLA film without and with honeycomb structure. NIH-3T3 and a much smaller Neuro-2A cells were cultivated on the films under various surface conditions. The results show that the two-step plasma treatment in combination with a honeycomb structure can enhance cell growth on PLA film, should the cell size be not too smaller than the pore size of honeycomb structure, e.g., NIH-3T3. Otherwise, cell growth would be better on flat PLA film, e.g., Neuro-2A.

Original languageEnglish
Pages (from-to)534-542
Number of pages9
JournalApplied Surface Science
Volume394
DOIs
StatePublished - 1 Feb 2017

Keywords

  • Atmospheric pressure plasma
  • Cell proliferation
  • Dielectric barrier discharge
  • Honeycomb structure
  • PLA
  • Surface modification

Fingerprint Dive into the research topics of 'Enhancement of cell growth on honeycomb-structured polylactide surface using atmospheric-pressure plasma jet modification'. Together they form a unique fingerprint.

  • Cite this