Enhanced cell stiffness evaluation by two-phase decomposition

Chia-Hung Tsai*, Makoto Kaneko, Shinya Sakuma, Fumihito Arai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

This work proposes an enhanced method for cell stiffness evaluation by eliminating the effect from cell viscosity. While the passing time of cell through a μ-channel is used for evaluating cell stiffness in the conventional method, the time includes both the effects of cell stiffness and cell viscosity. The key idea is that we separate the cell motion inside a μ-channel into two phases, the phases of deformation and constant velocity. We evaluate the cell stiffness by focusing on the cell motion in the phase of constant velocity. The results of experimental study are presented and discussed.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1009-1011
Number of pages3
ISBN (Print)9780979806452
StatePublished - 1 Jan 2012
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • Cell stiffness
  • Stiffness evaluation
  • μ-channel

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