Electrochemical imaging of cells and tissues

Tzu-En Lin, Stefania Rapino, Hubert H. Girault, Andreas Lesch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of single cell activity inside cell cultures, 3D cellular aggregates and microtissues is based on the selective detection of electroactive species involved in biological functions. Electrochemical imaging strategies, based on nano/micrometric probes scanning over the sample and sensor array chips, respectively, can be made sensitive and selective without being affected by optical interference as many other microscopy techniques. The recent developments in microfabrication, electronics and cell culturing/tissue engineering have evolved in affordable and fast-sampling electrochemical imaging platforms. We believe that the topics discussed herein demonstrate the applicability of electrochemical imaging devices in many areas related to cellular functions.

Original languageEnglish
Pages (from-to)4546-4554
Number of pages9
JournalChemical Science
Issue number20
StatePublished - 1 Jan 2018

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