Electrochemical determination of piroxicam on the surface of pyrolytic graphite electrode modified with a film of carbon nanoparticle-chitosan

Saeed Shahrokhian*, Effat Jokar, Masoumeh Ghalkhani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The electrochemical behavior of the anti-inflammatory drug piroxicam is studied at the surface of a plain pyrolytic graphite electrode modified with chitosan-doped carbon nanoparticles. An electroactive surface was produced by drop-casting a suspension of the modifier and characterized by atomic force microscopy. A remarkable enhancement is found in studies on the cyclic voltammetric response towards piroxicam. This is described on the basis of the thin-layer mass transport regimes within the porous films, which leads to a considerable increase in the active surface area of the electrode. The electrode shows a linear response to piroxicam in the range of 0.05-50 μM, with a detection limit of 25 nM (at S/N of 3). The electrode was successfully applied to the determination of piroxicam in pharmaceutical and clinical preparations with satisfactory accuracy and precision.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalMicrochimica Acta
Volume170
Issue number1
DOIs
StatePublished - Aug 2010

Keywords

  • Carbon nanoparticles
  • Chitosan
  • Cyclic voltammetry
  • Modified electrode
  • Piroxicam

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