Electroanatomic remodeling of the left stellate ganglion after myocardial infarction

Seongwook Han, Kenzaburo Kobayashi, Boyoung Joung, Gianfranco Piccirillo, Mitsunori Maruyama, Harry V. Vinters, Keith March, Shien-Fong Lin, Changyu Shen, Michael C. Fishbein, Peng Sheng Chen, Lan S. Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Objectives: The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Background: Whether MI results in remodeling of extracardiac nerve activity remains unclear. Methods: We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control. Results: MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at baseline to 8.09 ± 7.75 Ln(Vs)/day after the MI (p < 0.05). The 24-h integrated VNA before and after the MI was 5.29 ± 5.04 Ln(Vs)/day and 5.58 ± 5.15 Ln(Vs)/day, respectively (p < 0.05). A significant 24-h circadian variation was noted for the SGNA (p < 0.05) but not the VNA. The SGNA/VNA ratio also showed significant circadian variation. The nerve densities from the left SG were 63,218 ± 34,719 μm 2/mm 2 and 20,623 ± 4,926 μm 2/mm 2 for growth-associated protein 43 (p < 0.05) and were 32,116 ± 8,190 μm 2/mm 2and 16,326 ± 4,679 μm 2/mm 2 for synaptophysin (p < 0.05) in MI and control groups, respectively. The right SG also showed increased nerve density after MI (p < 0.05). Conclusions: MI results in persistent increase in the synaptic density of bilateral stellate ganglia and is associated with increased SGNA and VNA. There is a circadian variation of the SGNA/VNA ratio. These data indicate significant remodeling of the extracardiac autonomic nerve activity and structures after MI.

Original languageEnglish
Pages (from-to)954-961
Number of pages8
JournalJournal of the American College of Cardiology
Volume59
Issue number10
DOIs
StatePublished - 6 Mar 2012

Keywords

  • acute myocardial infarction
  • autonomic nervous system
  • nerve recordings

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    Han, S., Kobayashi, K., Joung, B., Piccirillo, G., Maruyama, M., Vinters, H. V., March, K., Lin, S-F., Shen, C., Fishbein, M. C., Chen, P. S., & Chen, L. S. (2012). Electroanatomic remodeling of the left stellate ganglion after myocardial infarction. Journal of the American College of Cardiology, 59(10), 954-961. https://doi.org/10.1016/j.jacc.2011.11.030